Descartes 466 Int. A, Col. Villa Universidad, C.P. 80010 Culiacán, Sinaloa, México
+52 (667) 753-1584

Culiacán, Sin. México, DF.

Therapeutic efficacy of ozone in patients with diabetic foot

Therapeutic efficacy of ozone in patients with diabetic foot

Gregorio Martínez-Sánchez a, Saied M. Al-Dalain a, Silvia Menéndez b, Lamberto Re c,
Attilia Giuliani d, Eduardo Candelario-Jalil a, Hector Álvarez e,
José Ignacio Fernández-Montequín e, Olga Sonia León a,

aCenter of Studies for Research and Biological Evaluation (CEIEB-IFAL), University of Havana, Havana 10400, Cuba
b Ozone Research Center, Cuba
c Laboratory of Pharmacological Biotechnology, University of Ancona, 60131 Ancona, Italy
d Department of Chemistry and Medical Biochemistry, University of Milan, Via Saldini, 50-20133 Milan, Italy
e Institute of Angiology and Vascular Surgery, Cuba

Revista o sitio electrónico (URL) donde se publicó

European Journal of Pharmacology 523 (2005) 151–161

Fecha de Recibido


Fecha de Publicación


Ozone; Diabetes (and its complications); Diabetic foot; Oxidative stress; Antioxidant defense system


Oxidative stress is suggested to have an important role in the development of complications in diabetes. Because ozone therapy can activate the antioxidant system, influencing the level of glycemia and some markers of endothelial cell damage, the aim of this study was to investigate the therapeutic efficacy of ozone in the treatment of patients with type 2 diabetes and diabetic feet and to compare ozone with antibiotic therapy. A randomized controlled clinical trial was performed with 101 patients divided into two groups: one (n=52) treated with ozone (local and rectal insufflation of the gas) and the other (n=49) treated with topical and systemic antibiotics. The efficacy of the treatments was evaluated by comparing the glycemic index, the area and perimeter of the lesions and biochemical markers of oxidative stress and endothelial damage in both groups after 20 days of treatment. Ozone treatment improved glycemic control, prevented oxidative stress, normalized levels of organic peroxides, and activated superoxide dismutase. The pharmacodynamic effect of ozone in the treatment of patients with neuroinfectious diabetic foot can be ascribed to the possibility of it being a superoxide scavenger. Superoxide is considered a link between the four metabolic routes associated with diabetes pathology and its complications. Furthermore, the healing of the lesions improved, resulting in fewer amputations than in control group. There were no side effects. These results show that medical ozone treatment could be an alternative therapy in the treatment of diabetes and its complications.


Leave a reply