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Ozone Therapy for Tumor Oxygenation: a Pilot Study

Ozone Therapy for Tumor Oxygenation: a Pilot Study

Bernardino Clavo1,5, Juan L. Pérez2,5, Laura López1,5, Gerardo Suárez1,5, Marta Lloret1,5, Victor Rodríguez3, David Macías2,5, Maite Santana1, María A. Hernández1,5, Roberto Martín-Oliva2 and Francisco Robaina 4,5.

Radiation Oncology and Research Unit, 2 Medical Physics, 3 La Paterna Medical Center, 4Chronic Pain Unit, Dr Negrín Hospital and 5 Canary Islands Institute for Cancer Research (ICIC), Las Palmas (Canary Islands), Spain

Revista o sitio electrónico (URL) donde se publicó

eCAM 2004;1(1)93–98

Cancer – hypoxia – pO2 measurement – polarographic probe


Tumor hypoxia is an adverse factor for chemotherapy and radiotherapy. Ozone therapy is a nonconventional form of medicine that has been used successfully in the treatment of ischemic disorders.This prospective study was designed to assess the effect of ozone therapy on tumor oxygenation. Eighteen subjects were recruited for the study. Systemic ozone therapy was administered by autohemotransfusion on three alternate days over one week. Tumor oxygenation levels were measured using polarographic needle probes before and after the first and the third ozone therapy session. Overall, no statistically significant change was observed in the tumor oxygenation in the 18 patients. However, a significant decrease was observed in hypoxic values ≤10 and ≤5 mmHg of pO2. When individually assessed, a significant and inverse non-linear correlation was observed between increase in oxygenation and the initial tumor pO2 values at each measuring time-point, thus indicating that the more poorly-oxygenated tumors benefited most (rho = –0.725; P= 0.001). Additionally, the effect of ozone therapy was found to be lower in patients with higher hemoglobin concentrations (rho = –0.531; P<0.034). Despite being administered over a very short period, ozone therapy improved oxygenation in the most hypoxic tumors. Ozone therapy as adjuvant in chemo-radiotherapy warrants further research.


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