Ozone in fibroblast growth factor activation
Re, Lamberto, Martínez-Sánchez, Gregorio, Perez-Davison, Gema; Sirito, Mario
Basic fibroblast growth factor (bFGF) is a pleiotropic mitogen which plays an important role in cell growth, differentiation, migration, and survival in different cells and organ systems. Application of bFGF has been shown to promote cellular proliferation and collagen synthesis in vivo. FGF is markedly up-regulated following bone or tendon injury and are active at multiple stages of the healing process stimulation, of local blood circulation, lipolisis and smooth muscle. Looking at physic and chemical properties of the ozone molecule, the present work deals the possible therapeutic action as a FGF activator. Incubation (2 h) of platelet rich plasma with O2/O3 80 μg/mL increases in approximately 600% the basal concentration of FGF. This fact in combination with previous demonstration of the stimulating action of O3, releasing other platelet factors may potentially possible the autologous treatment in aesthetic and clinical tissues conditions in which FGF has a protagonist role. The versatility and amplitude of beneficial effect of ozone has become evident in orthopedics, cutaneous and mucosal infections as well as in dentistry, the induction of FGF and other growth factors by ozone can support and potentiate those applications.