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Effect of ozone therapy on cerebral blood flow: A preliminary report

Effect of ozone therapy on cerebral blood flow: A preliminary report.

Bernardino Clavo 1,2,7, M.D.; Luis Catalá 3,7, M.D.; Juan L. Pérez 2,4,7, B.Sc.; Victor Rodríguez 5, M.D.;
Francisco Robaina 2,6,7, Ph.D.

From: Departments of 1Radiation Oncology, 2Research Unit, 3Radiology, 4Medical Physics and
6Chronic Pain Unit, from the Dr. Negrín Hospital, Las Palmas (Canary Islands) Spain.
5La Paterna Medical Center, Las Palmas (Canary Islands) Spain.
7Canary Islands Institute for Cancer Research (ICIC), Las Palmas (Canary Islands) Spain.

Color Doppler, ischemia, low perfusion, transcranial Doppler


Currently, ozone therapy is being used to treat ischemic disorders but the underlying mechanisms for the success are not well known. This study assesses the effect of ozone therapy on middle cerebral artery and common carotid artery blood flow.

Patients and methods

Seven study subjects were recruited for therapy performed with ozoneenriched autologous blood transfused on three alternate days over one week. Common carotid artery blood flow quantification (n = 14) was by color Doppler. Systolic and diastolic velocities in middle cerebral artery (n = 14) were by transcranial Doppler. Ultrasound assessments were conducted at three time-points: 1) basal (before ozone therapy) 2) after the 3rd session of ozone therapy 3) one week after the 3rd session of ozone therapy.


Relative to baseline, common carotid blood-flow was increased by 75% after the 3rd session of ozone therapy (p < 0.001) and by 29% one week later (p = 0.039). In middle cerebral artery the systolic velocity was increased by 22% after the 3rd session (p = 0.001) and by 15% one week later (p
= 0.035), while diastolic velocity was increased by 33% after the 3rd session (p < 0.001) and by 18% one week later (p = 0.023).


This preliminary Doppler study supports clinical experiences of improvement with ozone therapy in peripheral ischemic syndromes. Its potential usefulness as a complementary treatment in cerebral low perfusion syndromes merits further clinical evaluation.


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