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Ozone as U-Shaped dose responses molecules (Hormetins)

Ozone as U-Shaped dose responses molecules (Hormetins)

G. Martínez- Sánchez, G. Pérez-Davison Medinat srl Clinic, Camerano, Italy
L. Re  Medinat srl Clinic, Camerano, Italy; Pharmacology, D.I.S.M.A.R.,
University of Ancona, Italy
A. Giuliani Department of Chemistry and Medical Biochemistry, Univ. of
Milan, Milan, Italy


Redox environment involves a broad network of pro-oxidant and antioxidant components. Health benefit or damage can be induced as a consequence of an adaptive cellular stress response. A consequence of hormetic amplification is an increase in the homeodynamic space of a living system in terms of an increased defense capacity and a reduced load of damaged macromolecules. Ozone, when used at appropriate doses, promotes the formation of reactive oxygen species and lipid peroxides allows them to become late and long-lasting messengers. Healthy aging may be achieved by hormesis through mild and periodic, but not severe or chronic, physical and mental challenges, and by the use of nutritional hormesis incorporating mild stress-inducing molecules called hormetins. The paradoxical concept that ozone eventually induces an antioxidant response capable of reversing a chronic oxidative stress is common in the animal and vegetal kingdom; it is already supported by findings of an increased level of antioxidant enzymes during ozone therapy. Those facts can include ozone as a hormetin. The established scientific foundations of hormesis are ready to pave the way for new and effective approaches in redoxrelated disease research and intervention; ozone therapy can be a good candidate.


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