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Scientific and Medical Aspects of Ozone Therapy. State of the Art

Scientific and Medical Aspects of Ozone Therapy. State of the Art

Velio Alvaro Bocci

Department of Physiology, University of Siena, Siena, Italy

Revista o sitio electrónico (URL) donde se publicó

Archives of Medical Research

Fecha de Recibido


Fecha de Publicación


Ozone, Antioxidants, Oxidative stress, Ozone tolerance, Ozone therapy.


It is distressing to note that often ozone therapists are more interested in simply knowing the ozone dosage rather than to understand how ozone acts and why we can avoid toxicity. This behavior reveals a lack of knowledge of the fundamental bases regulating a judicious use of ozone and is the result of a superficial preparation acquired during an occasional ozone therapy’s course of a few hours. This is not surprising because during the last three decades, on the basis of Wolff’s suggestion (1), ozone therapy has been used by practitioners in Europe in an empirical fashion. Unfortunately, even today, most ozone therapists have either a misconception or know only a few technical tips for performing ozone therapy. This problem, associated with the difficulties and cost of performing extensive clinical studies, has hindered real progress, and ozone therapy remains a scarcely known and objected complementary practice. Worst of all, in some countries, often without any medical qualification, quacks continue to inject either ozone intravenously, a procedure prohibited since 1984 in Germany because of the risk of pulmonary embolism and death, or ozonated saline containing a certain toxic amount of hypochloric acid. Moreover, a distinguished American chemist has affirmed the dogma that ‘‘ozone is toxic any way you deal with it,” reinforcing the concept that ozone should never be used in medicine. This situation has generated a sort of crusade against ozone therapy in spite of the fact that ozone is considered one of the best disinfectants capable of preventing infection outbreaks. This is becoming a crucial advantage because critically ill patients acquire infections while in hospitals and a number of them die every year as a result.


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